Skip to main content

Publications

Nanobody nuclear imaging allows noninvasive quantification of LAG-3 expression by tumor-infiltrating leukocytes and predicts response of immune checkpoint blockade. Lecocq Q, Awad RM, De Vlaeminck Y, De Mey W, Ertveldt T, Goyvaerts C, Raes G, Thielemans K, Keyaerts M, Devoogdt N, Breckpot K.J Nucl Med. 2021 Mar 12:jnumed.120.258871. doi: 10.2967/jnumed.120.258871

The Next-Generation Immune Checkpoint LAG-3 and Its Therapeutic Potential in Oncology: Third Time's a Charm. Lecocq Q, Keyaerts M, Devoogdt N, Breckpot K.Int J Mol Sci. 2020 Dec 23;22(1):75. doi: 10.3390/ijms22010075.

Targeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development.De Vlaeminck Y, Bonelli S, Awad RM, Dewilde M, Rizzolio S, Lecocq Q, Bolli E, Santos AR, Laoui D, Schoonooghe S, Tamagnone L, Goyvaerts C, Mazzone M, Breckpot K, Van Ginderachter JA.Cancers (Basel). 2020 Nov 30;12(12):3582. doi: 10.3390/cancers12123582.

Theranostics in immune-oncology using nanobody derivatives. Lecocq Q, De Vlaeminck Y, hanssens H, D’Huyvetter M, Raes G, Goyvaerts C, Keyaerts M, Devoogdt N, Breckpot K. Theranostics 2019; 9(25):7772-7791. Doi:10.7150/thno.34941.

Noninvasive Imaging of the Immune Checkpoint LAG-3 Using Nanobodies, from Development to Pre-Clinical Use. Lecocq Q, Zeven K, De Vlaeminck Y, Martens S, Massa S, Goyvaerts C, Raes G, Keyaerts M, Breckpot K, Devoogdt N. Biomolecules. 2019 Sep 29;9(10). pii: E548. doi: 10.3390/biom9100548. PubMed PMID: 31569553.

Single Domain Antibody-Mediated Blockade of Programmed Death-Ligand 1 on Dendritic Cells Enhances CD8 T-cell Activation and Cytokine Production. Broos K, Lecocq Q, Keersmaecker B, Raes G, Corthals J, Lion E, Thielemans K, Devoogdt N, Keyaerts M, Breckpot K. . Vaccines (Basel). 2019 Aug 7;7(3). pii: E85. doi: 10.3390/vaccines7030085. PubMed PMID: 31394834; PubMed Central PMCID: PMC6789804.

Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent. Broos K, Lecocq Q, Xavier C, Bridoux J, Nguyen TT, Corthals J, Schoonooghe S, Lion E, Raes G, Keyaerts M, Devoogdt N, Breckpot K. Cancers (Basel). 2019 Jun 21;11(6). pii: E872. doi: 10.3390/cancers11060872. PubMed PMID: 31234464; PubMed Central PMCID: PMC6628009.

Perforin and Granzyme B Expressed by Murine Myeloid-Derived Suppressor Cells: A Study on Their Role in Outgrowth of Cancer Cells. Dufait I, Pardo J, Escors D, De Vlaeminck Y, Jiang H, Keyaerts M, De Ridder M, Breckpot K. Cancers (Basel). 2019 Jun 11;11(6). pii: E808. doi: 10.3390/cancers11060808. PubMed PMID: 31212684; PubMed Central PMCID: PMC6627828.

Single-domain antibody fusion proteins can target and shuttle functional proteins into macrophage mannose receptor expressing macrophages. De Vlaeminck Y, Lecocq Q, Giron P, Heirman C, Geeraerts X, Bolli E, Movahedi K, Massa S, Schoonooghe S, Thielemans K, Goyvaerts C, Van Ginderachter JA, Breckpot K. J Control Release. 2019 Feb 21;299:107-120. doi: 10.1016/j.jconrel.2019.02.023.

Epigenetic treatment of multiple myeloma mediates tumor intrinsic and extrinsic immunomodulatory effects. De Beck L, Melhaoui S, De Veirman K, Menu E, De Bruyne E, Vanderkerken K, Breckpot K, Maes K. Oncoimmunology. 2018 Jul 23;7(10):e1484981. doi: 10.1080/2162402X.2018.1484981

Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety. Van der Jeught K, De Koker S, Bialkowski L, Heirman C, Tjok Joe P, Perche F, Maenhout S, Bevers S, Broos K, Deswarte K, Malard V, Hammad H, Baril P, Benvegnu T, Jaffrès PA, Kooijmans SAA, Schiffelers R, Lienenklaus S, Midoux P, Pichon C, Breckpot K, Thielemans K. ACS Nano. 2018 Oct 23;12(10):9815-9829. doi: 10.1021/acsnano.8b00966. Epub 2018 Oct 1.

The Journey of in vivo Virus Engineered Dendritic Cells From Bench to Bedside: A Bumpy Road. Goyvaerts C, Breckpot K. Front Immunol. 2018 Sep 11;9:2052. doi: 10.3389/fimmu.2018.02052. eCollection 2018. Review.

Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression. Awad RM, De Vlaeminck Y, Maebe J, Goyvaerts C, Breckpot K. Front Immunol. 2018 Aug 31;9:1977. doi: 10.3389/fimmu.2018.01977. eCollection 2018. Review.

SHOW MORE

Key publications Movahedi Lab

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization.Pombo Antunes AR, Scheyltjens I, Lodi F, Messiaen J, Antoranz A, Duerinck J, Kancheva D, Martens L, De Vlaminck K, Van Hove H, Kjølner Hansen SS, Bosisio FM, Van der Borght K, De Vleeschouwer S, Sciot R, Bouwens L, Verfaillie M, Vandamme N, Vandenbroucke RE, De Wever O, Saeys Y, Guilliams M, Gysemans C, Neyns B, De Smet F, Lambrechts D, Van Ginderachter JA, Movahedi K. Nat Neurosci. 2021 Apr;24(4):595-610. doi: 10.1038/s41593-020-00789-y. 

Identifying the variables that drive tamoxifen-independent CreERT2 recombination: Implications for microglial fate mapping and gene deletions.Van Hove H, Antunes ARP, De Vlaminck K, Scheyltjens I, Van Ginderachter JA, Movahedi K. Eur J Immunol. 2020 Mar;50(3):459-463. doi: 10.1002/eji.201948162. 

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.Van Hove H, Martens L, Scheyltjens I, De Vlaminck K, Pombo Antunes AR, De Prijck S, Vandamme N, De Schepper S, Van Isterdael G, Scott CL, Aerts J, Berx G, Boeckxstaens GE, Vandenbroucke RE, Vereecke L, Moechars D, Guilliams M, Van Ginderachter JA, Saeys Y, Movahedi K. Nat Neurosci. 2019 Jun;22(6):1021-1035. doi: 10.1038/s41593-019-0393-4.   

RoMo: An efficient strategy for functional mosaic analysis via stochastic Cre recombination and gene targeting in the ROSA26 locus. Movahedi K, Wiegmann R, De Vlaminck K, Van Ginderachter JA, Nikolaev VO.Biotechnol Bioeng. 2018 Jul;115(7):1778-1792. doi: 10.1002/bit.26594. 

The Ontogeny and Microenvironmental Regulation of Tumor-Associated Macrophages. Movahedi K, Van Ginderachter JA.Antioxid Redox Signal. 2016 Nov 10;25(14):775-791. doi: 10.1089/ars.2016.6704. 

Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms. Movahedi K, Grosmaitre X, Feinstein P.Open Biol. 2016 Jul;6(7):160018. doi: 10.1098/rsob.160018.

SHOW MORE