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Running Projects

at the Laboratory for Molecular and Cellular Therapy

Cancer Immunotherapy group

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Karine Breckpot

Intravital imaging as tool to bridge the gap between macroscopic in vivo imaging and microscopic tissue analysis

17/06/2022
HERC56: Intravital imaging as tool to bridge the gap between macroscopic in vivo imaging and microscopic tissue analysis

Hernot, S. , Staels, W. , Hellemans, K. , Smolders, I. , Rooman, I. , Devoogdt, N. , Menu, E. , De Bundel, D. , Breckpot, K. , De Leu, N. , Movahedi, K. , D'Huyvetter, M....

Cofinancing OZR FWO Hercules MZW - High-parametric single-cell protein profiling in intact tissues

25/02/2022
OZR3913: Cofinancing OZR FWO Hercules MZW - High-parametric single-cell protein profiling in intact tissues

Movahedi, K. , van Grunsven, L. , Rooman, I. , Van Ginderachter, J. , Smolders, I. , Neyns, B. , Vanhaecke, T. , Laoui, D. , Breckpot, K. , De Veirman, K. , Stijlemans, B. , Van...

Exploring the mechanisms of RESponse and RESistance to novel Cancer immunotherapies in tumors Unresponsive to Earlier immune checkpoint inhibition

28/01/2022
FWOEOS18: Exploring the mechanisms of RESponse and RESistance to novel Cancer immunotherapies in tumors Unresponsive to Earlier immune checkpoint inhibition

Neyns, B. , Breckpot, K. & Tuyaerts, S.

1/01/22 → 31/12/25

Project : Fundamental

TITAN: imaging and manipulation of Tumor-Infiltrating T-Cells using Anti-CD3 Nanobodies

08/11/2021
ANI304: TITAN: imaging and manipulation of Tumor-Infiltrating T-Cells using Anti-CD3 Nanobodies

Breckpot, K. & Ceuppens, H.

1/11/21 → 31/10/22

Project : Fundamental

IOF PoC “MOTIF: MOdification of T cells In situ for altered Functionality”

12/01/2021
IOFPOC42: IOF PoC “MOTIF: MOdification of T cells In situ for altered Functionality”

Devoogdt, N. , Breckpot, K. , Meeus, F. , De Groof, T. & De Vlaeminck, Y.

1/01/21 → 31/12/22

Project : Applied

High intensity focused ultrasound and mRNA nanomedicines: a new strategy to induce and boost anti-tumor immunity

22/12/2020
FWOAL1019: High intensity focused ultrasound and mRNA nanomedicines: a new strategy to induce and boost anti-tumor immunity

Breckpot, K.

1/01/21 → 31/12/24

Project : Fundamental

Cancer Immunotherapy group

Cleo

Cleo Goyvaerts

Creation of a 3D CRiMe scene to unravel Cytotoxic T cell Resistant Mechanisms in NSCLC

Although immunotherapy became a first line treatment option for lung cancer patients, more than 75% of patients do not show any clinical benefit. Hence, there is an urgent need to study and identify novel Cytotoxic T-cell Resistance Mechanisms (CRMs), installed upon immunoediting. Therefore, we propose to develop a dynamic 3D CRM screening assay that combines tumor antigen-specific cytotoxic T-cell killing with RNA sequencing (RNAseq) to enable RNAseq-directed CRISPR-Cas9 mediated functional CRM validation.

Bone marrow niche – lung cancer X-talk: gossip or fatal choice of words?

Tumor infiltrating myeloid cells have been shown to play crucial roles in lung tumor progression next to resistance to (immuno)therapy. Although the bone marrow niche (BMN) represents the main source of myeloid cells, it is heavily understudied in solid cancer patients. Via this interdisciplinary crosstalk (X-talk) project, we aspire to deliver crucial fundamental biological knowledge on the X-talk between progressing lung tumors and the BMN. More specifically, we aim to optimize and apply an innovative 3D platform to study murine, human, and patient-derived lung tumor – BMN X-talk on the single cell level.  

Brain Immunology group

kiavash movahedi

Kiavash Movahedi

Back up mandate Research Council (Monica Vara Perez): Brain macrophages and stress: it takes two to tango

05/07/2022
OZR3973: Back up mandate Research Council (Monica Vara Perez): Brain macrophages and stress: it takes two to tango

Vara Pérez, M. & Movahedi, K.

1/10/22 → 30/09/23

Project : Fundamental

MyeCellTherapy: A novel myeloid-based cell therapy for glioblastoma, using genetically enhanced iPSCs-derived macrophages (iGEMs).

28/06/2022
FWOTM1105: MyeCellTherapy: A novel myeloid-based cell therapy for glioblastoma, using genetically enhanced iPSCs-derived macrophages (iGEMs).

Mampay, M. & Movahedi, K.

1/10/22 → 30/09/25

Project : Fundamental

SPECY-SORT: SPEctral flow CYtometer and cell SORTer

17/06/2022
HERC58: SPECY-SORT: SPEctral flow CYtometer and cell SORTer

Laoui, D. , De Veirman, K. , Van der Henst, C. , Brunner, J. , Messens, J. , Raes, G. , Van Ginderachter, J. , Devoogdt, N. , Magez, S. , Remaut, H. K. , Stijlemans, B. , Movahedi, K. , Peeters, E. & De Trez, C....

Intravital imaging as tool to bridge the gap between macroscopic in vivo imaging and microscopic tissue analysis

17/06/2022
HERC56: Intravital imaging as tool to bridge the gap between macroscopic in vivo imaging and microscopic tissue analysis

Hernot, S. , Staels, W. , Hellemans, K. , Smolders, I. , Rooman, I. , Devoogdt, N. , Menu, E. , De Bundel, D. , Breckpot, K. , De Leu, N. , Movahedi, K. , D'Huyvetter, M....

Cofinanciering OZR FWO Hercules MZW: SPECY-SORT: SPEctral flow CYtometer and cell SORTer

27/04/2022
OZR3941: Cofinanciering OZR FWO Hercules MZW: SPECY-SORT: SPEctral flow CYtometer and cell SORTer

Laoui, D. , Van Ginderachter, J. , Movahedi, K. , De Veirman, K. , Magez, S. , De Trez, C. , Stijlemans, B. , Raes, G. , Devoogdt, N. , Messens, J. , Brunner, J. , Remaut, H. K. , Fioravanti, A. ,...

Cofinancing OZR FWO Hercules MZW - High-parametric single-cell protein profiling in intact tissues

25/02/2022
OZR3913: Cofinancing OZR FWO Hercules MZW - High-parametric single-cell protein profiling in intact tissues

Movahedi, K. , van Grunsven, L. , Rooman, I. , Van Ginderachter, J. , Smolders, I. , Neyns, B. , Vanhaecke, T. , Laoui, D. , Breckpot, K. , De Veirman, K. , Stijlemans, B. , Van...